The Bioavailability of CBD

Cannabidiol (CBD) is available in various forms such as tinctures, capsules, vape oils, topicals and edibles. How you consume CBD determines its strength as well as distribution in your body. It also affects the bioavailability of CBD, or the percentage that’s absorbed in the bloodstream after the body finishes processing it. Here’s an intro to the bioavailability of the most popular methods of consuming CBD.


You can inhale CBD via infused vape liquids using a vaporizer pen. The bioavailability of this method is the highest of all forms of CBD – almost 56 percent! CBD enters your bloodstream directly through your lungs. Vaping CBD has a higher bioavailability than ingesting it because you avoid first-pass metabolism. The concentration of your vape liquid, volume of inhalation, and duration of vapor held in your lungs all affect the bioavailability of CBD when vaped. Despite these variables, it remains the most effective option for getting CBD into your bloodstream.


Sublingual (under the tongue) consumption can be done with products like concentrates, tinctures, sprays and lozenges. This is by far the most popular way to take CBD, simply because it is the easiest. When you use this method, the product absorbs via the mucous membranes under your tongue. It then enters your bloodstream, bypassing the first-pass metabolism and increasing its bioavailability up to 25 percent.


This method is very popular because it is convenient. Ingestible CBD products come in a variety of delicious flavors. Oral consumption can include various products such as oils, capsules and edibles. The substance passes through your digestive system, which metabolizes it before entering the blood stream. This first-pass metabolism reduces the overall bioavailability of CBD. Its bioavailability ranges from 4% to 20% when you take it orally.

Factors That Affect Bioavailability

Metabolism and method absorption can both reduce the bioavailability of CBD. CBD oil is hydrophobic (afraid of water), and this also affects its bioavailability. Since it doesn’t dissolve in water, it gathers in fatty tissues and diffuses out of your bloodstream. This lessens the quantity of active CBD in your system over time. Potency and dosage of product have an effect on how long CBD lasts in your body. With plenty of options for taking CBD, we guarantee you can find a method that works for you.

Which Method is Right for You?

The best method differs from one person to another. If it is your first time to use CBD, it is a good idea to follow dosing instructions on your product label. If you do not experience the desired effect after a few servings, you can titrate to a higher amount over time until you find an amount that works for you. It is also important to consider that different concentrations are available in different CBD products. A higher concentration may be more effective for your needs. Reputable providers will have testing results that confirm the CBD level they advertise. Get CBD products from a reliable source that provides information about the products they offer. This way, you can guarantee that you are taking a safe, effective, high-quality product.